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This breakthrough is a crucial step in advancing our understanding of drug-receptor interactions.Researchers at the PSI Center for Life Sciences and leadXpro AG, located in Switzerland Innovation Park Innovaare, have leveraged a photoswitchable caffeine derivative to study ligand dissociation from a G protein-coupled receptor (GPCR). GPCRs are complex biological transmembrane receptors that are notoriously challenging to study due to their dynamic and heterogeneous nature but are important drug targets. For example, the studied human adenosine A2a receptor is targeted for treating conditions like Parkinson’s disease.The team successfully captured molecular dynamics at millisecond timescales using time-resolved serial crystallography (TRSX) at MAX IV Laboratory in Lund, Sweden. This achievement was made possible by the exceptional spatial and temporal resolution provided by this 4th-generation synchrotron.Read more about the study: https://www.nature.com/articles/s41467-024-55109-w#Sec9

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• Author: Switzerland Innovation Digital
• Published Date: 1/20/2025 5:23:39 PM
• Modified Date: 1/20/2025 5:23:39 PM

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This breakthrough is a crucial step in advancing our understanding of drug-receptor interactions.

Researchers at the PSI Center for Life Sciences and leadXpro AG, located in Switzerland Innovation Park Innovaare, have leveraged a photoswitchable caffeine derivative to study ligand dissociation from a G protein-coupled receptor (GPCR).

GPCRs are complex biological transmembrane receptors that are notoriously challenging to study due to their dynamic and heterogeneous nature but are important drug targets. For example, the studied human adenosine A2a receptor is targeted for treating conditions like Parkinson’s disease.

The team successfully captured molecular dynamics at millisecond timescales using time-resolved serial crystallography (TRSX) at MAX IV Laboratory in Lund, Sweden. This achievement was made possible by the exceptional spatial and temporal resolution provided by this 4th-generation synchrotron.

Read more about the study: https://www.nature.com/articles/s41467-024-55109-w#Sec9